Cent Eur J Public Health 2019, 27(4):267-271 | DOI: 10.21101/cejph.a5601
Family history and cord blood eosinophil count as predictors for atopic manifestations
- 1 General County Hospital Požega, Požega, Croatia
- 2 School of Medicine, University of Osijek, Osijek, Croatia
- 3 Centre for Research and Knowledge Transfer in Biotechnology, University of Zagreb, Zagreb, Croatia
Objectives: The aim of our study was to investigate the correlation between several clinical parameters and the appearance of atopic manifestations (atopic eczema, food allergy, wheezing bronchitis, allergic rhinoconjunctivitis) in the first four years of life.
Methods: A total of 139 unselected full-term newborns were included in a prospective follow up from birth to age 4. Cord blood total immunoglobulin E (cIgE) and cord blood absolute eosinophil count (cEo), positive family history of allergy, maternal smoking during pregnancy, mode of delivery, and duration of exclusive and overall breastfeeding were evaluated as predictors for appearance of atopic manifestations.
Results: We found that children with a positive family history of both mother and father are 19.03 times more likely to develop atopic manifestations and those with a positive family history of only mothers are 12.55 times more likely to develop atopy compared with children with a negative family history. Neonates with cord blood eosinophilia had 5.30 times higher chances for developing atopic manifestations. No statistically significant associations were found between cIgE (p = 0.099), mode of delivery (p = 0.379), maternal smoking (p = 0.661), exclusive (p = 0.867) and overall breastfeeding duration (p = 0.675) and the presence of atopic manifestations up to age 4.
Conclusions: A positive medical history, especially of mothers and cEo, seem to be predictive in screening for the onset of allergic diseases.
Klíčová slova: allergy, children, family history, cord blood, eosinophils
Vloženo: 13. listopad 2018; Revidováno: 20. říjen 2019; Přijato: 20. říjen 2019; Zveřejněno: 31. prosinec 2019 Zobrazit citaci
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Reference
- Liu T, Valdez R, Yoon PW, Crocker D, Moonesinghe R, Khoury MJ. The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 1999-2004. Genet Med. 2009;11(5):323-8.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Stick SM, Burton PR, Gurrin L, Sly PD, Le Souef PN. Effect of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants. Lancet. 1996;348(9034):1060-4.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Svanes C, Omenaas E, Jarvis D, Chinn S, Gulsvik A, Burney P. Parental smoking in childhood and adult obstructive lung disease: results from The European Community Respiratory Health Survey. Thorax. 2004;59(4):295-302.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Noakes PS, Holt PG, Prescott SL. Maternal smoking in pregnancy alters neonatal cytokine responses. Allergy. 2003;58(10):1053-8.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Renz-Polster H, David MR, Buist AS, Vollmer WM, O'Connoor EA, Frazier EA, et al. Caesarean section delivery and the risk of allergic disorders in childhood. Clin Exp Allergy. 2005;35(11):1466-72.
Přejít k původnímu zdroji...
Přejít na PubMed...
- McKeever TM, Lewis SA, Smith C, Hubbard R. Mode of delivery and risk of developing allergic disease. J Allergy Clin Immunol. 2002;109(5):800-2.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Pesonen M, Kallio MJT, Siimes MA, Elg P, Björksten F, Ranki A. Cord serum Immunoglobulin E as a risk factor for allergic symptoms and sensitization in children and young adults. Pediatr Allergy Immunol. 2009;20(1):12-8.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Gleich GJ, Adolphson CR, Leiferman KM. The biology of the eosinophilic leukocyte. Annu Rev Med. 1993;44:85-101.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Schoetzau A, Filipiak-Pittroff B, Franke K, Koletzko S, Von Berg A, Gruebl A, et al. Effect of exclusive breast-feeding and early solid food avoidance on the incidence of atopic dermatitis in high-risk infants at 1 year of age. Pediatr Allergy Immunol. 2002:13(4):234-42.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Van Odijk J, Kull I, Borres MP, Brandtzaeg P, Edberg U, Hanson LÅ. Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact of later atopic manifestations. Allergy. 2003:58(9):833-43.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Kusunoki T, Morimoto T, Nishikomori R, Yasumi T, Heike T, Mukaida K, et al. Breastfeeding and the prevalence of allergic diseases in schoolchildren: Does reverse causation matter? Pediatr Allergy Immunol. 2010;21(1 Pt 1):60-6.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Hagendorens MM, Bridts CH, Lauwers K, van Nuijs S, Ebo DG, Vellinga A, et al. Perinatal risk factors for sensitization, atopic dermatitis and wheezing during the first year of life (PIPO study). Clin Exp Allergy. 2005;35(6):773-40.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Litonjua AA, Carey VJ, Burge HA, Weiss ST, Gold DR. Parental history and the risk for childhood asthma. Does mother confer more risk than father? Am J Respir Crit Care Med. 1998;158(1):176-81.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Saito S. Cytokine network at the feto-maternal interface. J Reprod Immunol. 2000;47(2):87-103.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Holt PG, Macaubas C. Development of long-term tolerance versus sensitisation to environmental allergens during the perinatal period. Curr Opin Immunol. 1997;9(6):782-7.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Matsumoto K, Shimanouchi Y, Kawakubo K, Oishi N, Wakiguchi H, Futamura K, et al. Infantile eczema at one month of age is associated with cord blood eosinophilia and subsequent development of atopic dermatitis and wheezing illness until two years of age. Int Arch Allergy Immunol. 2005;137 Suppl l:69-76.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Haus M, Hall JM, Heese H de V, Weinberg EG, Berman D. Cord blood and maternal total eosinophil counts in relation to infant allergy. Pediatr Allergy Clin Immunol. 1992;3:23-7.
Přejít k původnímu zdroji...
- Borres MP, Olderam H, Irander K, Kjellman NI, Björksten B. Peripheral blood eosinophilia in infants at 3 months of age is associated with subsequent development of atopic disease in early childhood. J Allergy Clin Immunol. 1995;95(3):694-8.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Borres MP, Björksten B: Peripheral blood eosinophils and IL-4 in infancy in relation to the appearance of allergic disease during the first 6 years of life. Pediatr Allergy Immunol. 2004;15(3):216-20.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Rossberg S, Gerhold K, Geske T, Zimmermann K, Menke G, Zaino M, et all. Elevated blood eosinophils in early infancy are predictive of atopic dermatitis in children with risk for atopy. Pedatr Allergy Immunol. 2016;27(7):702-8.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Annesi-Maesano I, Moreau D, Strachan D. In utero and perinatal complications preceding asthma. Allergy. 2001;56(6):491-7.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Lødrup Carlsen KC, Carlsen KH, Nafstad P, Bakketeig L. Perinatal risk factors for recurrent wheeze in early life. Pediatr Allergy Immunol. 1999;10(2):89-95.
Přejít k původnímu zdroji...
Přejít na PubMed...
- Høst A, Andrae S, Charkin S, Diaz-Vázquez C, Dreborg S, Eingenmann PA, et al. Allergy testing in children: why, who, when and how? Allergy. 2003;58(7):559-69.
Přejít k původnímu zdroji...
Přejít na PubMed...